Vibrio cholerae O1 clinical strains isolated in 1992 in Kolkata with progenitor traits of the 2004 Mozambique variant
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Vibrio cholerae O1 clinical strains isolated in 1992
in Kolkata with progenitor traits of the 2004
Mozambique variant
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| Creator |
Chatterjee, Souvik
Patra, Tapas Ghosh, Kausik Raychoudhuri, Amit Pazhani, Gururaja P Das, Mayukh Sarkar, Banwarilal Bhadra, Rupak K Mukhopadhyay, Asish K Takeda, Yoshifumi Nair, G. Balakrish Ramamurthy, Thandavarayan Nandy, Ranjan K |
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| Subject |
Infectious Diseases and Immunology
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| Description |
Retrospective analysis led to the detection of two Vibrio cholerae variant O1 strains (VC51 and
VC53), which were isolated in 1992 in Kolkata from clinical cases, with identical traits to 2004
Mozambique variant O1 strains. The Mozambique O1 strains that caused a huge outbreak in
2004 have been shown to have phenotypic traits of both classical and El Tor biotypes, and
thereby have been reported as variant. Our study demonstrated that two O1 strains isolated in
Kolkata during 1992 were of the El Tor background as evidenced by polymyxin B (50 U ml”1)
resistance, positivity in Voges–Proskauer reactions and sensitivity to biotype-specific vibrio
phages. With the features of classical CTX prophage, localization in the small chromosome, and
an absence of RS1 and pTLC, both Mozambique and Kolkata strains appeared to be identical.
Furthermore, two Kolkata strains exhibited an identical ribotype to that of the Mozambique variant,
displaying ribotype pattern RI that had been assigned to Kolkata V. cholerae O1 strains isolated
on or before 1992. NotI pulsotype analysis indicated that these 1992 Kolkata strains along with
the Mozambique variant O1 belonged to very closely related clones. Considering the
chronological events, and the typical identity at the phenotypic and the genotypic level between
the two O1 strains isolated during 1992 from Kolkata and during 2004 from Mozambique, we
propose that some of the 1992 Kolkata O1 strains might have acted as progenitors for
Mozambique variant O1 strains.
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| Date |
2009
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/203/1/JOURNAL_OF_MEDICAL_MICROBIOLOGY%2C_58(2)%2C_239%2D247%2C2009[106].pdf
Chatterjee, Souvik and Patra, Tapas and Ghosh, Kausik and Raychoudhuri, Amit and Pazhani, Gururaja P and Das, Mayukh and Sarkar, Banwarilal and Bhadra, Rupak K and Mukhopadhyay, Asish K and Takeda, Yoshifumi and Nair, G. Balakrish and Ramamurthy, Thandavarayan and Nandy, Ranjan K (2009) Vibrio cholerae O1 clinical strains isolated in 1992 in Kolkata with progenitor traits of the 2004 Mozambique variant. Journal of Medical Microbiology, 58 (2). pp. 239-247. |
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| Relation |
http://www.eprints.iicb.res.in/203/
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