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pH-Sensitive Nanostructural Transformation of a Synthetic Self-Assembling Water-Soluble Tripeptide: Nanotube to Nanovesicle

IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata


Field	Value

Title	pH-Sensitive Nanostructural Transformation of a Synthetic Self-Assembling Water-Soluble Tripeptide: Nanotube to Nanovesicle

Creator	Bose, Partha Pratim Das, Apurba Kr Hegde, Raghurama P Shamala, Narayanaswami Banerjee, Arindam

Subject	Chemistry

Description	Construction of various nanostructures using suitable self-assembling molecular building blocks is a challenging issue. Moreover, controlling the formation of a specific nanostructure from self-assembling molecular building blocks by tuning the pH of the solution is interesting. The present study demonstrates pH-responsive nanostructural transformation of a self-assembling water-soluble tripeptide from nanotubes to nanovesicles. In acidic pH (pH 4.3–5.5), hollow nanotubular structures have been observed, while at pH 6.5 (nearly neutral), both nanotubes and nanovesicles coexist uniformly. With an increase in the pH of the solution, only one nanoscopic species, i.e., nanovesicles, has been formed exclusively, and these hollow, fusible nanovesicles are stable within the range pH 7.0–9.2. A further increase in the pH triggers the rupture of these nanovesicles. pH-sensitive nanovesicle formation has been utilized for the entrapment and slow release of a physiological dye, Congo red.

Date	2007

Type	Article PeerReviewed

Format	application/pdf

Identifier	http://www.eprints.iicb.res.in/218/1/CHEMISTRY_OF_MATERIALS%2C19_(_25)%2C_6150%2D6157%2C2007[6].pdf Bose, Partha Pratim and Das, Apurba Kr and Hegde, Raghurama P and Shamala, Narayanaswami and Banerjee, Arindam (2007) pH-Sensitive Nanostructural Transformation of a Synthetic Self-Assembling Water-Soluble Tripeptide: Nanotube to Nanovesicle. Chem. Mater., 19. pp. 6150-6157.

Relation	http://dx.doi.org/10.1021/cm0716147 http://www.eprints.iicb.res.in/218/