Interaction of Isoquinoline Alkaloids with Polymorphic DNA Structures
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Interaction of Isoquinoline Alkaloids with Polymorphic DNA Structures
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| Creator |
Bhadra, Kakali
Maiti, Motilal Kumar, G Suresh |
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| Subject |
Chemistry
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| Description |
was studied. Berberine and palmatine showed moderate binding to the B form, while coralyne showed
higher binding, as revealed from spectroscopic and thermodynamic data. Berberine and coralyne binding
to the B form was exothermic and enthalpy-driven, while palmatine showed exothermic binding which
was favored by both negative enthalpy and negative entropy changes. Berberine and palmatine neither
bind nor converted the Z-form structure to B form. Coralyne, on the other hand, exhibited a strong
binding affinity to Z DNA structure that was enthalpy-driven. Berberine binding to the HL form was
cooperative, exothermic, and favored by both negative enthalpy and negative entropy changes with the
formation of an induced CD band. Palmatine showed weak binding, while coralyne showed a strong
binding with the HL form. The structural differences in the isoquinoline alkaloids appear to influence the
affinity and mode of interactions with these polymorphic DNA structures
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| Date |
2009
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/257/1/JOURNAL_OF_GENETICS%2C88(4)%2C451%2D467%2C2009[3].pdf
Bhadra, Kakali and Maiti, Motilal and Kumar, G Suresh (2009) Interaction of Isoquinoline Alkaloids with Polymorphic DNA Structures. Chemistry & Biodiversity, 6 (9). pp. 1323-1342. |
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| Relation |
http://dx.doi.org/ 10.1002/cbdv.200900017
http://www.eprints.iicb.res.in/257/ |
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