Effect of Fatty Acids Isolated from Edible Oils Like Mustard, Linseed or Coconut on Astrocytes Maturation
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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Title |
Effect of Fatty Acids Isolated from Edible Oils Like
Mustard, Linseed or Coconut on Astrocytes Maturation
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Creator |
Joardar, Anindita
Das, Sumantra |
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Subject |
Cell Biology & Physiology
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Description |
The omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA,
22:6n-3) has been previously shown to facilitate some of the vital functions of astrocytes.
Since some dietary oils contain a-linolenic acid (ALA, 18:3n-3), which is a precursor of
DHA, we examined their effect on astrocyte development. Fatty acids (FAs) were
isolated from commonly used oils and their compositions were determined by GLC.
FAs from three oils, viz. coconut, mustard and linseed were studied for their effect on
astrocyte morphology. Parallel studies were conducted with FAs from the same oils
after heating for 72 h. Unlike coconut oil, FAs from mustard and linseed, both heated
and raw, caused significant morphogenesis of astrocytes in culture. ß-AR binding was
also substantially increased in astrocytes treated with FAs from raw mustard and linseed
oils as compared to astrocytes grown in normal medium. The expression profile of the
isoforms of GFAP showed that astrocyte maturation by FAs of mustard and linseed oil
was associated with appearance of acidic variants of GFAP and disappearance of some
neutral isoforms similar to that observed in cultures grown in serum containing medium
or in the presence of DHA. Taken together, the study highlights the contribution of
specific dietary oils in facilitating astrocyte development that can have potential impact
on human health.
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Date |
2007
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Type |
Article
PeerReviewed |
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Format |
application/pdf
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Identifier |
http://www.eprints.iicb.res.in/259/1/CELLULAR_AND_MOLECULAR_NEUROBIOLOGY%2C_27(_8)%2C973%2D983_%2C_2007_[12].pdf
Joardar, Anindita and Das, Sumantra (2007) Effect of Fatty Acids Isolated from Edible Oils Like Mustard, Linseed or Coconut on Astrocytes Maturation. Cell Mol Neurobiol, 27 (8). pp. 973-983. |
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Relation |
http://dx.doi.org/10.1007/s10571-007-9204-7
http://www.eprints.iicb.res.in/259/ |
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