IL-10- and TGF-�-Mediated Susceptibility in Kala-azar and Post-kala-azar Dermal Leishmaniasis: The Significance of Amphotericin B in the Control of Leishmania donovani Infection in India1
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
IL-10- and TGF-�-Mediated Susceptibility in Kala-azar and
Post-kala-azar Dermal Leishmaniasis: The Significance of
Amphotericin B in the Control of Leishmania donovani
Infection in India1
|
|
| Creator |
Saha, Samiran
Mondal, Smriti Ravindran, Rajesh Bhowmick, Swati Modak, Dolanchampa Mallick, Sudeshna Rahman, Mehboobar Kar, Sourjya Goswami, Rama prosad Guha, Subhasis Kamal Pramanik, Netai Saha, Bibhuti Ali, Nahid |
|
| Subject |
Infectious Diseases and Immunology
|
|
| Description |
Visceral leishmaniasis (VL) or kala-azar is known to be associated with a mixed Th1-Th2 response, and effective host defense
requires the induction of IFN-� and IL-12. We address the role of the differential decline of IL-10 and TGF-� in response to
sodium antimony gluconate (SAG) and amphotericin B (AmB), the therapeutic success of SAG and AmB in Indian VL, and the
significance of IL-10 and TGF-� in the development and progression of post-kazla-azar dermal leishmaniasis (PKDL). In the
active disease, PBMC from VL patients showed suppressed Ag-specific lymphoproliferation, IFN-� and IL-12 production, and
elevation of IL-10 and TGF-�. Cure corresponded with an elevation in IFN-� and IL-12 production and down-regulation of IL-10
and TGF-�. Both CD4� and CD8� T cells were involved in IFN-� and IL-10 production. Interestingly, the retention and maintenance
of residual IL-10 and TGF-� in some SAG-treated individuals and the elevation of IL-10 and TGF-� in PKDL, a sequel
to kala-azar, probably reflects the role of these cytokines in reactivation of the disease in the form of PKDL. Contrastingly, AmB
treatment of VL resulted in negligible TGF-� levels and absolute elimination of IL-10, reflecting the better therapeutic activity of
AmB and its probable role in the recent decline in PKDL occurrences in India. Moreover, elucidation of immune responses in
Indian PKDL patients revealed a spectral pattern of disease progression where disease severity could be correlated inversely with
lymphoproliferation and directly with TGF-�, IL-10, and Ab production. In addition, the enhancement of CD4�CD25� T cells in
active VL, their decline at cure, and reactivation in PKDL suggest their probable immunosuppressive role in these disease
forms. The Journal of Immunology, 2007, 179: 5592–5603.
|
|
| Date |
2007
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://www.eprints.iicb.res.in/266/1/JOURNAL_OF_IMMUNOLOGY%2C_179(_8)%2C_5592%2D5603%2C2007[26].pdf
Saha, Samiran and Mondal, Smriti and Ravindran, Rajesh and Bhowmick, Swati and Modak, Dolanchampa and Mallick, Sudeshna and Rahman, Mehboobar and Kar, Sourjya and Goswami, Rama prosad and Guha, Subhasis Kamal and Pramanik, Netai and Saha, Bibhuti and Ali, Nahid (2007) IL-10- and TGF-�-Mediated Susceptibility in Kala-azar and Post-kala-azar Dermal Leishmaniasis: The Significance of Amphotericin B in the Control of Leishmania donovani Infection in India1. The Journal of Immunology, 179 (8). pp. 5592-5603. |
|
| Relation |
http://dx.doi.org/10.179;5592-5603
http://www.eprints.iicb.res.in/266/ |
|