HLA Class I–Restricted T Cell Epitopes of the Kinetoplastid Membrane Protein–11 Presented by Leishmania donovani–Infected Human Macrophages
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
HLA Class I–Restricted T Cell Epitopes
of the Kinetoplastid Membrane Protein–11
Presented by Leishmania donovani–Infected
Human Macrophages
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| Creator |
Basu, Rajatava
Roy, Syamal Walden, Peter |
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| Subject |
Infectious Diseases and Immunology
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| Description |
Visceral leishmaniasis is a protozoal disease caused by the intracellular parasites Leishmania donovani and L.
chagasi/infantum, and it is usually deadly if not treated. To date, no vaccine exists for prophylaxis or immunotherapy,
nor has it been established which effector mechanisms of the immune system are most instrumental
against the parasites. Recent reports have suggested that CD8+ T cells, in addition to CD4+ T cells,
might play major roles in the defense against infection and in the cure of the disease. To identify epitopes
recognized by CD8+ T cells that can be used for immune monitoring to investigate the role of these cells in
human visceral leishmaniasis, as well as in vaccine development, we scanned the entire sequence of the
leishmanial protein kinetoplastid membrane protein (kmp)–11 with overlapping nonapeptides. Thirty peptides
that specifically trigger interferon-g secretion by human CD8+ T cells were identified. Four T cell lines with
specificities for different peptides recognize Leishmania-infected autologous macrophages, which proves that
kmp-11 is processed and presented via the major histocompatibility complex class I pathway of infected cells.
Kmp-11 is thus a candidate antigen for the development of T cell vaccines.
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/351/1/JOURNAL_OF_INFECTIOUS_DISEASES%2C195(_9)%2C_1373%2D1380[94].pdf
Basu, Rajatava and Roy, Syamal and Walden, Peter (2007) HLA Class I–Restricted T Cell Epitopes of the Kinetoplastid Membrane Protein–11 Presented by Leishmania donovani–Infected Human Macrophages. The Journal of Infectious Diseases , 195 (9). pp. 1373-1380. |
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| Relation |
http://dx.doi.org/10.1086/513439
http://www.eprints.iicb.res.in/351/ |
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