Polymorphism in the ERCC2 codon 751 is associated with arsenic-induced premalignant hyperkeratosis and significant chromosome aberrations
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Polymorphism in the ERCC2 codon 751 is associated with arsenic-induced premalignant hyperkeratosis and significant chromosome aberrations
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| Creator |
Banerjee, Mayukh
Sarkar, Jyotirmoy Das, Jayanta K Mukherjee, Angshuman Sarkar, Ajoy K Mondal, Lakshmikanta Giri, Ashok K |
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| Subject |
Molecular & Human Genetics
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| Description |
Ground water in 9 out of 18 districts of West Bengal, India,
is contaminated with arsenic, concentrations ranging from
55 to 625 mg/l, much higher than the current permissible
maximum contamination level (1,2). More than 300 000
people show arsenic-induced skin lesions in these districts.
This is regarded as the greatest arsenic calamity in the
world. Chronic arsenicosis is associated with a wide array of
dermatological symptoms including palmo-planter hyperkeratosis,
raindrop pigmentation and hyperpigmentation.
Hyperkeratosis of skin is considered as a precursor of
arsenic-induced skin cancer (3,4), as skin cancers often
appear at the sites of existing hyperkeratosis (5). A strong
relationship between arsenic level in water with the prevalence
of hyperkeratosis and hyperpigmentation in the
exposed individuals has been reported earlier (6). Longterm
exposure to arsenic contaminated water causes a wide
range of adverse health effects including skin pigmentations,
hyperkeratosis, vascular diseases, conjunctivitis in the eyes,
neuropathy, lung diseases and non-melanocytic cancer of
skin and different internal organs (6). Strikingly enough, of
the huge number of people exposed to arsenic contaminated
drinking water, only 15–20% exhibit arsenic-specific skin
lesions (7). This fact suggests that genetic variability
might play a key role in arsenic-induced toxicity and
carcinogenicity.
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Relation |
http://dx.doi.org/10.1093/carcin/bgl181
http://www.eprints.iicb.res.in/369/ |
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| Identifier |
Banerjee, Mayukh and Sarkar, Jyotirmoy and Das, Jayanta K and Mukherjee, Angshuman and Sarkar, Ajoy K and Mondal, Lakshmikanta and Giri, Ashok K (2007) Polymorphism in the ERCC2 codon 751 is associated with arsenic-induced premalignant hyperkeratosis and significant chromosome aberrations. Carcinogenesis , 28 (3). pp. 672-676.
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