In Vitro Antileishmanial Activity of Aloe Vera Leaf Exudate: A Potential Herbal Therapy in leishmaniasis
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
In Vitro Antileishmanial Activity of Aloe Vera Leaf Exudate:
A Potential Herbal Therapy in leishmaniasis
|
|
| Creator |
Dutta, Avijit
Mandal, Goutam Mandal, Chitra Chatterjee, Mitali |
|
| Subject |
Infectious Diseases and Immunology
|
|
| Description |
Aloe vera has wide spread use in health products,
and despite several reports on the whole plant and inner gel, little work has been performed on the leaf exudate. Our aim was to evaluate the in vitro efficacy of Aloe vera leaf exudate (AVL) in leishmaniasis. Irrespective of the disease manifestation, promastigotes from strains responsible for cutaneous, mucocutaneous, and visceral leishmaniasis were susceptible to AVL and their IC50 ranged from 100 to 180 μg/ml. In axenic amastigotes cultured from a L. donovani strain 2001 responsible for visceral leishmaniasis, the IC50 was 6.0 μg/ml. AVL caused activation of host macrophages evident by an increased release of members of reactive oxygen species that was attenuated by preincubation with free radical scavengers. Collectively, our data indicates that AVL, via its direct leishmanicidal activity which can be further enhanced by activation of host macrophages, isan effective antileishmanial agent meriting further pharmacological
investigations.
|
|
| Date |
2007
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://www.eprints.iicb.res.in/385/1/GLYCOCONJUGATE_JOURNAL%2C__24_(_1)%2C_81%2D86%2C2007_[135].pdf
Dutta, Avijit and Mandal, Goutam and Mandal, Chitra and Chatterjee, Mitali (2007) In Vitro Antileishmanial Activity of Aloe Vera Leaf Exudate: A Potential Herbal Therapy in leishmaniasis. Glycoconjugate Journal, 24 (1). pp. 81-86. |
|
| Relation |
http://dx.doi.org/10.1007/s10719-006-9014-z
http://www.eprints.iicb.res.in/385/ |
|