O-Acetylation of Sialic Acids is Required for the Survival of Lymphoblasts in Childhood Acute Lymphoblastic leukemia (ALL)
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
O-Acetylation of Sialic Acids is Required for the Survival
of Lymphoblasts in Childhood Acute Lymphoblastic
leukemia (ALL)
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| Creator |
Ghosh, Shyamasree
Bandyopadhyay, Suman Mukherjee, Kankana Mallick, Asish Pal, Santanu Mandal, Chhabinath Bhattacharya, Dilip K Mandal, Chitra |
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| Subject |
Infectious Diseases and Immunology
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| Description |
Exploiting the selective affinity of Achatinin-H
towards 9-O-acetylneuraminic acid(α2-6)GalNAc, we have
demonstrated the presence of 9-O-acetylated sialoglycoproteins
(Neu5,9Ac2-GPs) on hematopoietic cells of children
suffering from acute lymphoblastic leukemia (ALL), indicative
of defective sialylation associated with this disease.
The carbohydrate epitope of Neu5,9Ac2-GPsALL was
confirmed by using several synthetic sialic acid analogues.
They are functionally active signaling molecules as demonstrated
by their role in mediating lymphoproliferative
responses and consequential increased production of IFN-γ
due to specific stimulation of Neu5,9Ac2-GPs on
PBMCALL with Achatinin-H. Cells devoid of 9-Oacetylations
(9-O-AcSA−) revealed decreased nitric oxide
production as compared to 9-O-AcSA+ cells on exposure to
IFN-γ. Under this condition, a decrease in viability of 9-OAcSA−
cells as compared to 9-O-AcSA+ cells was also
observed which was reflected from increased caspase 3
activity and apoptosis suggesting the protective role of this
glycotope.
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/386/1/GLYCOCONJUGATE_JOURNAL%2C_24(_1)%2C__17%2D24_%2C2007_[134].pdf
Ghosh, Shyamasree and Bandyopadhyay, Suman and Mukherjee, Kankana and Mallick, Asish and Pal, Santanu and Mandal, Chhabinath and Bhattacharya, Dilip K and Mandal, Chitra (2007) O-Acetylation of Sialic Acids is Required for the Survival of Lymphoblasts in Childhood Acute Lymphoblastic leukemia (ALL). Glycoconjugate Journal , 24 (1). pp. 17-24. |
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| Relation |
http://dx.doi.org/10.1007/s10719-006-9007-y
http://www.eprints.iicb.res.in/386/ |
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