MAOA Promoter Polymorphism and Attention Deficit Hyperactivity Disorder (ADHD) in Indian Children
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
MAOA Promoter Polymorphism and Attention Deficit
Hyperactivity Disorder (ADHD) in Indian Children
|
|
| Creator |
Das, Manali
Das Bhowmik, Aneek Sinha, Swagata Chattopadhyay, Anindita Chaudhuri, Keya Singh, Manoranjan Mukhopadhyay, Kanchan |
|
| Subject |
Molecular & Human Genetics
|
|
| Description |
Attention deficit hyperactivity disorder (ADHD)
is a highly disabling, early onset childhood neurobehavioral
disorder with a higher occurrence in
boys as compared to girls. Pharmacological and
molecular genetic studies have revealed the
influence of dopaminergic and serotonergic systems
in the etiology of the disorder. Monoamine
oxidase A (MAOA) is a mitochondrial enzyme that
regulates the dopaminergic signals in the presynaptic
region. Polymorphism in the promoter
region of theMAOAgene, which comprises of 30 bp
repeats with repeat number varying between 2.5,
3.5, 4.5, and 5.5, has been shown to be associated
with various neurobehavioral disorders including
ADHD. This is the first study on Indian ADHD
cases to validate an association between transmission
of MAOA promoter polymorphism and
risk of ADHD. We have analyzed the MAOA
promoter polymorphism in a group of ADHD
probands, their parents and ethnically matched
controls by UNPHASED. Our findings indicate
significant difference in the frequency of 3.5
repeat allele (P¼0.02) between cases and controls
and preferential transmission of the short allele
(3.5 repeat) from mothers to maleADHDprobands
(P¼0.005). We conclude that the short 3.5 repeat
allele of the MAOA-u VNTR is probably associated
with ADHD in our population and could be the
reason for making boys prone to ADHD as compared
to girls.
|
|
| Date |
2006
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://www.eprints.iicb.res.in/403/1/AMERICAN_JOURNAL_OF_MEDICAL_GENETICS_PART_B%2DNEUROPSYCHIATRIC_GENETICS%2C_141B(6)637%2D642_[38].pdf
Das, Manali and Das Bhowmik, Aneek and Sinha, Swagata and Chattopadhyay, Anindita and Chaudhuri, Keya and Singh, Manoranjan and Mukhopadhyay, Kanchan (2006) MAOA Promoter Polymorphism and Attention Deficit Hyperactivity Disorder (ADHD) in Indian Children. American Journal of Medical Genetics, 141B (6). pp. 637-642. |
|
| Relation |
http://dx.doi.org/10.1002/ajmg.b.30385
http://www.eprints.iicb.res.in/403/ |
|