Association of Dopamine D4 Receptor (DRD4) Polymorphisms With Attention Deficit Hyperactivity Disorder in Indian Population
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Association of Dopamine D4 Receptor (DRD4)
Polymorphisms With Attention Deficit Hyperactivity
Disorder in Indian Population
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| Creator |
Bhaduri, Nipa
Das, Manali Sinha, Swagata Chattopadhyay, Anindita Gangopadhyay, Prasanta Kumar Chaudhuri, Keya Singh, Manoranjan Mukhopadhyay, Kanchan |
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| Subject |
Molecular & Human Genetics
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| Description |
Attention deficit hyperactivity disorder (ADHD)
is a childhood onset neurobehavioral disorder.
Several studies worldwide have implicated a
possible associationbetweenADHDandtransmission
of different polymorphisms of the dopamine
D4 receptor gene (DRD4) in different ethnic
groups. However, this is the first report on the
transmission of different polymorphisms of DRD4
in Indian subjects. Association of 50 flanking 120-
bp duplication, exon 1 12-bp duplication, and exon
3 48-bp variable numbers of tandem repeats
(VNTR) were analyzed in 50 ADHD cases. Haplotype-
based haplotype relative risk (HHRR) analysis
and transmission disequilibrium test (TDT)
were carried out to ascertain the association of
these polymorphisms with the disorder. Linkage
disequilibria (LD) between the polymorphisms
were calculated using EHþ and 2LD programs.
Our preliminary data showed lack of association
betweenADHDand transmission of the 50 flanking
120-bp duplication and exon 1 12-bp duplication.
But, the transmissions of 6 and 7 repeat alleles of
exon 3 48-bpVNTRshowed significant association
with ADHD. We have also examined the haplotype
frequencies and biased transmission of one
haplotype was observed in ADHD probands. LD
analysis showed very strong disequilibrium
between exon 1 12-bp duplication and exon 3
48-bp VNTR. Strong LD was also observed between
the 50 flanking 120-bp duplication and exon
1 12-bp duplication. The observed association between
higher repeat alleles of exon 3 48-bp VNTR
and Indian ADHD children is consistent with
some of the earlier reports. � 2005 Wiley-Liss, Inc.
KEY WORDS: ADHD; DRD4; HHRR; TDT;
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| Date |
2006
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/404/1/AMERICAN_JOURNAL_OF_MEDICAL_GENETICS_PART_B%2DNEUROPSYCHIATRIC_GENETICS%2C_141B(_1)%2C_61%2D66__[144].pdf
Bhaduri, Nipa and Das, Manali and Sinha, Swagata and Chattopadhyay, Anindita and Gangopadhyay, Prasanta Kumar and Chaudhuri, Keya and Singh, Manoranjan and Mukhopadhyay, Kanchan (2006) Association of Dopamine D4 Receptor (DRD4) Polymorphisms With Attention Deficit Hyperactivity Disorder in Indian Population. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics), 141B. pp. 61-66. |
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| Relation |
htpp://dx.doi.org/10.1002/ajmg.b.30225
http://www.eprints.iicb.res.in/404/ |
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