Synthesis of Bioactive Polynuclear Heteroaromatics Mainly based on Indoles and Quinolines
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Synthesis of Bioactive Polynuclear Heteroaromatics Mainly based on Indoles and Quinolines
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| Creator |
Hazra, Abhijit
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| Subject |
Chemistry
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| Description |
The thesis embodies the results of studies on “Synthesis of bioactive polynuclear
heteroaromatics mainly based on indoles and quinolines”. Most of the biologically
active compounds contain various heterocyclic moieties as one of their main
attention-grabbing unit. Among these indole and quinoline derivatives have been
topics of substantial research interest and covers the most areas of heterocyclic
chemistry, particularly due to their natural occurrences and pharmacological
activities. A large number of indole as well as quinoline derivatives are to the fore as
pharmacologically active lead compounds for drug development. Indole and
quinoline moieties also occur widely in many natural products. Chemical and
biological research has now presented a great challenge to synthesize and optimise
highly efficient and cost-effective synthetic routes to some unique and novel
biologically active substances. Among these polynuclear heteroaromatics are an
imperative structural class due to their high degree of biological efficacy. Polynuclear
heteroaromatics, an area of enormous interest, includes every single type of
heterocyclic system (N, O, or S) along with fused, bridged as well as spiro annulated
ring systems.
The study covers the synthesis of various polynuclear indoles, oxindoles and
quinolines and also some other heterocyclic ring systems attached to indoles or
quinolines through simple intermolecular bridging or fused or through spiro linkage
by using some time-honored reaction conditions as well as through the development
of new methodology and also bioevaluation of some of these analogues.
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| Date |
2010
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/425/1/Thesis%2D_Abhijit_Hazra_(Dr._N.B.Mondal).pdf
Hazra, Abhijit (2010) Synthesis of Bioactive Polynuclear Heteroaromatics Mainly based on Indoles and Quinolines. PhD thesis, Jadavpur University. |
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| Relation |
http://www.eprints.iicb.res.in/425/
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