Functional Delivery of a Cytosolic tRNA into Mutant Mitochondria of Human Cells
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Functional Delivery of a Cytosolic tRNA into Mutant Mitochondria of Human Cells
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| Creator |
Mahata, Bidesh
Mukherjee, Saikat Mishra, Sumita Bandyopadhyay, Arun Adhya, Samit |
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| Subject |
Molecular & Human Genetics
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| Description |
Many maternally inherited and incurable neuromyopathies are caused by mutations in mitochondrial
(mt) transfer RNA (tRNA) genes. Kinetoplastid protozoa, including Leishmania, have evolved specialized
systems for importing nucleus-encoded tRNAs into mitochondria. We found that the Leishmania RNA
import complex (RIC) could enter human cells by a caveolin-1–dependent pathway, where it induced
import of endogenous cytosolic tRNAs, including tRNALys, and restored mitochondrial function in a
cybrid harboring a mutant mt tRNALys (MT-TK) gene. The use of protein complexes to modulate
mitochondrial function may help in the management of such genetic disorders.
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| Date |
2006
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/489/1/SCIENCE%2C_314(_5798)%2C_471%2D474_[24].pdf
Mahata, Bidesh and Mukherjee, Saikat and Mishra, Sumita and Bandyopadhyay, Arun and Adhya, Samit (2006) Functional Delivery of a Cytosolic tRNA into Mutant Mitochondria of Human Cells. Science, 314 (5798). pp. 471-474. |
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| Relation |
http://dx.doi.org/10.1126/science.1130276
http://www.eprints.iicb.res.in/489/ |
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