Protein Association : It's Quantitative Structural Evaluation In Biological Processes.
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Protein Association : It's Quantitative Structural Evaluation In Biological Processes.
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| Creator |
Nath, Sangeeta
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| Subject |
Structural Biology & Bioinformatics
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| Description |
Proteins, central-working molecules of cell, are known to be the most abundant polymers of nature consisting 50 % or more of the dry weight of cells. Most importantly they are the molecular instruments through which genetic information is expressed. They are playing crucial roles in almost all biological processes from catalysis, transport, storage, regulatory and immune response including cell-cell recognition and signaling.
Proteins have an underlying chemical unity; are made up of sequential arrangements of 20 amino acids without branching, which are building block of polypeptide or backbone of protein chain. They have ability to fold in different three-dimensional structures, which are
responsible for cellular functions. Their sequence and folding patterns allow enormous versatility in their properties. Protein structure is not rigid; it is dynamic in nature and the changes are dependent on surrounding environmental conditions. Quite a few diseases stem
from mutations and conformational changes in proteins. The ultimate goal of protein science is to predict the structure and activity of a protein de novo, how it will bind to ligands and also interrelation between them. These in totality will lead to structural and
functional phonemics.
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| Date |
2006
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/622/1/thesis.pdf
Nath, Sangeeta (2006) Protein Association : It's Quantitative Structural Evaluation In Biological Processes. PhD thesis, Jadavpur University. |
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| Relation |
http://www.eprints.iicb.res.in/622/
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