Cationic liposome-encapsulated antisense oligonucleotide mediates efficient killing of intracellular Leishmania
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Cationic liposome-encapsulated antisense oligonucleotide mediates efficient
killing of intracellular Leishmania
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| Creator |
Chakroborty, Rila
Dasgupta, Dalia Adhya, Samit Basu, Mukul K |
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| Subject |
Molecular & Human Genetics
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| Description |
Antisense oligonucleotides have been considered as inhibitors of
growth of intracellular parasites such as Leishmania, but only
limited inhibition has been observed in �itro. We have encapsulated
an antisense oligonucleotide, complementary to the
Leishmania universal miniexon sequence, in cationic liposomes.
Low concentrations (4 lM) of encapsulated oligonucleotides
speci®cally reduced the amastigote burden within cultured macrophages by 80%. This result illustrates the importance of effective
delivery for efficient antiparasitic activity of antisense oligonucleotides
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| Publisher |
Portland Press
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| Date |
1999
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/652/1/BIOCHEMICAL_JOURNAL340%2C_393%2D396;1999[46].pdf
Chakroborty, Rila and Dasgupta, Dalia and Adhya, Samit and Basu, Mukul K (1999) Cationic liposome-encapsulated antisense oligonucleotide mediates efficient killing of intracellular Leishmania. Biochemical Journal, 340. pp. 393-396. ISSN 0264-6021 |
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| Relation |
http://dx.doi.org/10.1042/0264-6021:3400393
http://www.eprints.iicb.res.in/652/ |
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