Mitochondrial Dysfunction in Parkinson’s Disease
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Mitochondrial Dysfunction in Parkinson’s Disease
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| Creator |
Varghese, Merina
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| Subject |
Cell Biology & Physiology
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| Description |
Parkinson’s disease (PD, also referred to as sporadic or idiopathic PD and primary parkinsonism) is a progressive motor disorder that occurs in old age and is characterized by resting tremor, rigidity and slowness of movement. It is named after James Parkinson, the physician whose description of PD is one of the early authoritative accounts of the disease(Parkinson 1817). He called it the shaking palsy or paralysis agitans. Earlier references to
the symptoms of PD may be found in Indian and Egyptian texts (García Ruiz 2004).Parkinson, referring to previous accounts of tremor and palsy by Galen, Sylvius de la Boë,
Boissier de Sauvages and Gaubius, stressed on the distinctive tremor that occurs in the absence of voluntary activity in PD patients (resting tremor) and the tendency of patients to run when attempting to walk (festinating gait). He also described the slowness in initiating
movement (bradykinesia), freezing (akinesia), postural instability, difficulty in performing complex activities like writing, sleep disturbance and drooling seen in PD. Jean-Martin Charcot (1877) gave PD its present name and added to the description given by Parkinson the symptoms of masked facies, rigidity and the non-motor symptoms (reviewed by Elmer 2005). The secondary non-motor symptoms of PD include autonomic dysfunction, depression and dementia.
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| Date |
2008
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/691/1/PhD_Thesis%2DMerina_Varghese%2C_IICB.pdf
Varghese, Merina (2008) Mitochondrial Dysfunction in Parkinson’s Disease. PhD thesis, Jadavpur University. |
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| Relation |
http://www.eprints.iicb.res.in/691/
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