Anomalies in Hepatobiliary Excretion of Technetium-99m-MAG3 Preparations
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Anomalies in Hepatobiliary Excretion of Technetium-99m-MAG3 Preparations
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| Creator |
Chatterjee, Mita
Majumder, Arupesh Iyer, Priya Muthukrishnan, G Das, M K Ramamoorthy, N Desai, C N Banerjee, Somnath |
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| Subject |
Chemistry
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| Description |
Technetium-99m-MAG, is accepted as a renal tubular function agent. However, sporadic
liver and gall bladder visualisation during its clinical use is clearly a disadvantage. HPLC-purified 99mTc-
MAG, samples. exhibited appreciable hepatobiliary uptake (7%), and an elevated level of such uptake was
observed in unpurified kit preparations, which was stated to be associated with the excretory property
of the radiolabeled kit impurities. To verify this we attempted to quantitate the hepatobiliary uptake of
the kit preparations with that of its radiolabeled components. The contribution of each component to-
ward hepatobiliary uptake of the sample was calculated from their abundance in the chelate mixture
and the individual biodistribution of the isolated components. However, the anticipated hepatobiliary uptake
of different preparations of 99mTc*MAG, calculated in this way was always lower than that of the experi-
mental value determined directly. Further work is needed to explain the anomaly.
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| Date |
1996
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/723/1/NUCLEAR_MEDICINE_AND_BIOLOGY%2C_23(_7)%2C_867%2D872[14].pdf
Chatterjee, Mita and Majumder, Arupesh and Iyer, Priya and Muthukrishnan, G and Das, M K and Ramamoorthy, N and Desai, C N and Banerjee, Somnath (1996) Anomalies in Hepatobiliary Excretion of Technetium-99m-MAG3 Preparations. Nuclear Medicine & Biology, 23 (7). pp. 867-872. |
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| Relation |
http://dx.doi.org/10.1016/S0969-8051(96)00116-3
http://www.eprints.iicb.res.in/723/ |
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