Inhibition of platelet aggregation and immunomodulation of NK lymphocytes by administration of ascorbic acid
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Creator |
Toliopoulos, Ioannis K.
Simos, Yannis V. Daskalou, Telemachos A. Verginadis, Ioannis I. Evangelou, Angelos M. Karkabounas, Spyros C. |
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| Date |
2011-11-30T09:35:15Z
2011-11-30T09:35:15Z 2011-12 |
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| Identifier |
0975-1009 (Online); 0019-5189 (Print)
http://hdl.handle.net/123456789/13095 |
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| Description |
904-908
Platelets aggregation around migrating tumor cells offers protection against the cytotoxic activity of the natural killers cells (NKC). The ascorbic acid in 3X10<sup>-3</sup>Μ concentration completely inhibited platelet aggregation, decreased thromboxane B<sub>2 </sub>levels, and inhibited the expression of platelet membranic receptor GpIIb/IIIa in non stimulated platelets, and increased the NKC cytotoxicity in an average rate of 105, 61, and 285% in the NKC/targets cells ratios 12.5:1, 25:1 and 50:1 respectively. The results suggest the role of ascorbic acid in increasing the susceptibility of tumor cells to NKC; the ascorbic acid could be used as part of a multidrug therapy to treat diseases which up to now have been treated only through chemotherapy. |
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| Language |
en_US
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| Publisher |
NISCAIR-CSIR, India
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Source |
IJEB Vol.49(12) [December 2011]
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| Subject |
Ascorbic acid
Natural killer cells Platelet glycoprotein GpIIb-IIIa complex Thromboxane B<sub>2</sub> |
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| Title |
Inhibition of platelet aggregation and immunomodulation of NK lymphocytes by administration of ascorbic acid
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| Type |
Article
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