Antiinflammatory, analgesic and antipyretic activities of <i style="">Linum usitatissimum</i> L. (flaxseed/linseed) fixed oil
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Creator |
Kaithwas, Gaurav
Mukherjee, Alok Chaurasia, A K Majumdar, Dipak K |
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| Date |
2011-11-30T09:38:16Z
2011-11-30T09:38:16Z 2011-12 |
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| Identifier |
0975-1009 (Online); 0019-5189 (Print)
http://hdl.handle.net/123456789/13100 |
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| Description |
932-938
The fixed oil of <i>L. </i><i style="">usitatissimum</i> (flaxseed/linseed) inhibited PGE<sub>2</sub>-, leukotriene-, histamine- and bradykinin-induced inflammation. The oil also inhibited arachidonic acid-induced inflammation, suggesting its capacity to inhibit both cyclooxygenase and lipoxygenase pathways of arachidonate metabolism. In tail immersion model, the oil raised the pain threshold to a lesser extent than morphine but showed excellent peripherally acting, analgesic activity comparable to aspirin, against acetic acid-induced writhing in mouse. In typhoid paratyphoid A/B vaccine-induced pyrexia, the oil showed antipyretic activity comparable to aspirin. <span style="color: rgb(51, 51, 51);">The oil contains 57.38% <img src='http://www.niscair.res.in/jinfo/Alpha.gif' border=0>-linolenic acid. Dual inhibition of arachidonic acid metabolism, antihistaminic and antibradykinin activities of the oil could account for the biological activity and the active principle could be <img src='http://www.niscair.res.in/jinfo/Alpha.gif' border=0>-linolenic acid an omega-3 (18:3, n-3) fatty acid. </span> |
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| Language |
en_US
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| Publisher |
NISCAIR-CSIR, India
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Source |
IJEB Vol.49(12) [December 2011]
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| Subject |
Antibradykinin
Antihistaminic Arachidonic acid Dual-inhibitor <img src='http://www.niscair.res.in/jinfo/Alpha.gif' border=0>-Linolenic acid |
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| Title |
Antiinflammatory, analgesic and antipyretic activities of <i style="">Linum usitatissimum</i> L. (flaxseed/linseed) fixed oil
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| Type |
Article
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