Amarogentin, a Naturally Occurring Secoiridoid Glycoside and a Newly Recognized Inhibitor of Topoisomerase I from Leishmania donouani
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Amarogentin, a Naturally Occurring Secoiridoid Glycoside and a Newly
Recognized Inhibitor of Topoisomerase I from Leishmania donouani
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| Creator |
Ray, Sutapa
Majumder, Hemanta K Chakravarty, Ajit K Mukhopadhyay, Sibabrata |
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| Subject |
Chemistry
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| Description |
A MeOH extract of Swertia chirata found to inhibit the catalytic activity of topoisomerase I of
Leishmania donovani was subjected to fractionation to yield three secoiridoid glycosides:
amarogentin (11, amaroswerin (21, and sweroside (3). Amarogentin is a potent inhibitor of
type I DNA topoisomerase from Leishmania and exerts its effect by interaction with the enzyme,
preventing binary complex formation.
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| Date |
1996
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/739/1/JOURNAL_OF_NATURAL_PRODUCTS%2C_59(_1)%2C_27%2D29%2C_DOI_10.1021np960018g%2C1996_[67].pdf
Ray, Sutapa and Majumder, Hemanta K and Chakravarty, Ajit K and Mukhopadhyay, Sibabrata (1996) Amarogentin, a Naturally Occurring Secoiridoid Glycoside and a Newly Recognized Inhibitor of Topoisomerase I from Leishmania donouani. Journal of Natural Products, 59 (1). pp. 27-29. |
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| Relation |
http://www.eprints.iicb.res.in/739/
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