Antimutagenic Effects of Black Tea (World Blend) and its two Active Polyphenols Theaflavins and Thearubigins in Salmonella Assays
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Antimutagenic Effects of Black Tea (World
Blend) and its two Active Polyphenols
Theaflavins and Thearubigins in Salmonella
Assays
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| Creator |
Gupta, S
Chaudhuri, T Seth, P Ganguly, D K Giri, Ashok K |
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| Subject |
Molecular & Human Genetics
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| Description |
Almost two thirds of the world population consume tea everyday. Tea is processed differently in different
parts of the world to give green (20%), black (78%) or oolong tea (2%). The antimutagenic and anticarcinogenic
activities of green tea were extensively investigated compared with those of black tea. Considering
the potent antimutagenic effects of green tea we recognized the need to evaluate the antimutagenic
effects of black tea (World Blend Tea, Southern Tea Co., Marietta, GA) in Salmonella strains TA97a,
TA98, TA100 and TA102 in preincubation tests, both with and without S9 activation. Attempts have also
been made to compare the results of the tea extracts with their two active polyphenols theaflavins and
thearubigins. Antimutagenicity assays were carried out in bacterial plates treated with different concentrations
(1%, 2.5%, 5%, 10% and 20%) of tea extracts against known bacterial mutagens sodium azide,
4-nitro-o-phenylenediamine, cumine hydroperoxide, 2-aminofluorene and danthron. A significant
decrease in the number of revertant colonies was observed in the plates treated with 1% to 20% of tea
extract plus positive mutagen when compared with positive mutagen only. Both the active polyphenols
theaflavins and thearubigins extracted from the black tea (World blend) also showed significant antimutagenic
effects against known positive compounds in these strains. In the experiments with S9 activation,
the antimutagenic effects were significantly higher. These results indicate that black tea and its two polyphenols
have significant antimutagenic effects in Ames Salmonella assays. Copyright � 2002 John Wiley
& Sons, Ltd.
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| Publisher |
John Wiley & Sons
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| Date |
2002
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/785/1/PHYTOTHERAPY_RESEARCH__16_(7)_655%2D661;2002[19].pdf
Gupta, S and Chaudhuri, T and Seth, P and Ganguly, D K and Giri, Ashok K (2002) Antimutagenic Effects of Black Tea (World Blend) and its two Active Polyphenols Theaflavins and Thearubigins in Salmonella Assays. Phytotherapy Research, 16 (7). pp. 655-661. ISSN 0951-418X |
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| Relation |
http://dx.doi.org/10.1002/ptr.1038
http://www.eprints.iicb.res.in/785/ |
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