Antidiarrhoeal Activity of Seed Extract of Albizzia lebbeck Benth.
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Antidiarrhoeal Activity of Seed Extract of
Albizzia lebbeck Benth.
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| Creator |
Besra, S E
Gomes, Aparna Chaudhury, L Vedasiromoni, J R Ganguly, D K |
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| Subject |
Drug Development/Diagnostics & Biotechnology
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| Description |
The antidiarrhoeal activity of the seed extract of Albizzia lebbeck (Benth.) was investigated employing
conventional rodent models of diarrhoea, i.e. castor oil-induced diarrhoea, upper gastrointestinal transit
(u.g.t.) and fluid secretion. It was found that the aqueous methanol extract of Albizzia lebbeck seeds (2.5–
5 mg/kg i.p.) possessed antidiarrhoeal activity which strengthens the earlier use of the seeds in the treatment
of diarrhoea and dysentery. The antidiarrhoeal dose of the extract was at least 10–30 times less
than the LD50 dose. The extract (2.5–5 mg/kg i.p.) potentiated the antidiarrhoeal activity of loperamide
(1 mg/kg i.p.). Nalaxone (0.5 mg/kg i.p.) significantly inhibited the antidiarrhoeal activity of the extract as
well as loperamide, thus indicating a role of the opioid system in the antidiarrhoeal activity of the
extract.
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| Publisher |
John Wiley & Sons
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| Date |
2002
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/786/1/PHYTOTHERAPY_RESEARCH__16(_6)_529%2D533;2002[31].pdf
Besra, S E and Gomes, Aparna and Chaudhury, L and Vedasiromoni, J R and Ganguly, D K (2002) Antidiarrhoeal Activity of Seed Extract of Albizzia lebbeck Benth. Phytotherapy Research, 16 (6). pp. 529-533. ISSN 0951-418X |
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| Relation |
http://dx.doi.org/10.1002/ptr.961
http://www.eprints.iicb.res.in/786/ |
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