Extrathyroidal actions of Antithyroid Thionamides
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Extrathyroidal actions of Antithyroid Thionamides
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| Creator |
Bandyopadhyay, Uday
Biswas, Kausik Banerjee, Ranajit K |
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| Subject |
Cell Biology & Physiology
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| Description |
Some compounds having thionamide structure inhibit thyroid functions. Such antithyroid thionamides include
mercaptomethylimidazole (methimazole), thiourea and propylthiouracil, of which mercaptomethylimidazole is widely
used to treat hyperthyroidism. Undesirable side effects develop from these drugs due to extrathyroidal actions.
Antithyroid thionamides inhibit lactoperoxidase which contributes to the antibacterial activities of a number of
mammalian exocrine gland secretions that protect a variety of mucosal surfaces. These drugs stimulate both gastric
acid and pepsinogen secretions, thereby augmenting the severity of gastric ulcers and preventing wound healing.
Increased gastric acid secretion is partially due to the H2 receptor activation, and also through the stimulation of the
parietal cell by intracellular generation of H2O2 following inactivation of the gastric peroxidase–catalase system.
Severe abnormalities may develop in blood cells and the immune system after thionamide therapy. It causes
agranulocytosis, aplastic anemia, and purpura along with immune suppression. Olfactory and auditory systems are
also affected by these drugs. Thionamide affects the sense of smell and taste and also causes loss of hearing. It binds
to the Bowman’s glands in the olfactory mucosa and causes extensive lesion in the olfactory mucosa. Thionamides
also affect gene expression and modulate the functions of some cell types. A brief account of the chemistry and
metabolism of antithyroid thionamides, along with their biological actions are presented. © 2002 Elsevier Science
Ireland Ltd. All rights reserved.
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| Publisher |
Elsevier
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| Date |
2002
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/790/1/TOXICOLOGY_LETTERS__128_(1%2D3)_117%2D127;2002[61].pdf
Bandyopadhyay, Uday and Biswas, Kausik and Banerjee, Ranajit K (2002) Extrathyroidal actions of Antithyroid Thionamides. Toxicology Letters, 128 (1-3). pp. 117-127. |
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| Relation |
http://dx.doi.org/10.1016/S0378-4274(01)00539-2
http://www.eprints.iicb.res.in/790/ |
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