CSIR Central

Haplotype Analysis of Genomic Polymorphisms in and Around the Myotonic Dystrophy Locus in Diverse Populations of India

IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata


Field	Value

Title	Haplotype Analysis of Genomic Polymorphisms in and Around the Myotonic Dystrophy Locus in Diverse Populations of India

Creator	Basu, Priyadarshi Majumder, Partha P Roychoudhury, Susanta Bhattacharyya, Nitai P

Subject	Molecular & Human Genetics

Description	The frequencies of haplotypes based upon the (CTG)n repeat and three other biallelic markers in and around the myotonic dystrophy (DM) locus were estimated in 13 ethnically, linguistically and geographically diverse sub-populations of India. The range of CTG repeats in caste populations was 5–31, while in tribal populations the range was shorter (5–23). Extensive variation in frequencies of large (CTG)n alleles (≥18 repeats) was found in Indian populations. The implications of this finding on DM epidemiology are discussed. Haplotype diversity was found to be very high in most populations. The majority of the Indian DM patients carried a haplotype that is commonly found among DM patients globally; this is the most common haplotype in the class of large (≥18 repeats) CTG alleles. However, one haplotype was found to be present in particularly high frequency in Indian populations; this haplotype was also found among Indian DM patients. This haplotype may be a characteristic of Indian and possibly of other East Asian populations.

Date	2001

Type	Article PeerReviewed

Format	application/pdf

Identifier	http://www.eprints.iicb.res.in/909/1/HUMAN_GENETICS%2C_108(_4)%2C_310%2D317%2C2001[47].pdf Basu, Priyadarshi and Majumder, Partha P and Roychoudhury, Susanta and Bhattacharyya, Nitai P (2001) Haplotype Analysis of Genomic Polymorphisms in and Around the Myotonic Dystrophy Locus in Diverse Populations of India. Human Genetics, 108 (4). pp. 310-317.

Relation	http://dx.doi.org/10.1007/s004390100479 http://www.eprints.iicb.res.in/909/