Glycosylated molecular variants of C-reactive proteins from the major carp Catla catla in fresh and polluted aquatic environments
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Glycosylated molecular variants of C-reactive
proteins from the major carp Catla catla in fresh
and polluted aquatic environments
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| Creator |
Paul, Indrani
Mandal, Chhabinath Allen, Anthony K Mandal, Chitra |
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| Subject |
Infectious Diseases and Immunology
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| Description |
Elevated level of pollutant specific glycosylated molecular variants of C-reactive protein have been purified to electrophoretic
homogeneity from the sera of major carp, Catla catla confined in freshwater (CRPN) and water polluted with
nonlethal doses of cadmium (CRPCd), mercury (CRPHg), phenol (CRPPh) and hexachlorocyclohexane (CRPHex). These CRPs
differ amongst themselves in electrophoretic mobility, and in their carbohydrate content ranging from 20–50%. CRPs interact
with pneumococcal C-polysaccharide (CPS) showing different binding constants. Both phosphorylcholine (PC) and
calcium are indispensable for binding. Studies on amino acid compositions, electrophoretic analysis, isoelectric focusing, binding to PC & CPS and secondary structures of the purified CRPs indicate, that, they differ from each other. However, they share the common properties of a CRP, including pentraxin structure revealed by electron microscopy. Taken together, our results provide a new structural insight regarding the connection between the presence of unique molecular variants and probably the toxicity therein combated.
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| Date |
2001
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/910/1/GLYCOCONJUGATE_JOURNAL%2C_18(7)%2C_547%2D556%2C2001[31].pdf
Paul, Indrani and Mandal, Chhabinath and Allen, Anthony K and Mandal, Chitra (2001) Glycosylated molecular variants of C-reactive proteins from the major carp Catla catla in fresh and polluted aquatic environments. Glycoconjugate Journal, 18 (7). pp. 547-556. |
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| Relation |
http://dx.doi.org/10.1023/A:1019696430477
http://www.eprints.iicb.res.in/910/ |
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