Attempts to characterize the mechanisms involved in the growth inhibition of Mycobacterium microti in interferon-gamma or tumor necrosis factor-alpha activated J774A.1 cells.
IR@IMTECH: CSIR-Institute of Microbial Technology, Chandigarh
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| Title |
Attempts to characterize the mechanisms involved in the growth inhibition of Mycobacterium microti in interferon-gamma or tumor necrosis factor-alpha activated J774A.1 cells.
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| Creator |
Gupta, R
Dogra, N Raje, Manoj Majumder, S |
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| Subject |
QR Microbiology
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| Description |
The growth of Mycobacterium microti was inhibited within J774A.1 macrophage cells activated with either interferon-gamma or tumor necrosis factor-alpha. Activation with interferon-gamma or tumor necrosis factor-alpha alone did not stimulate the production of nitrite in J774A.1 cells. Interferon-gamma but not tumor necrosis factor-alpha increased the production of hydrogen peroxide in a concentration dependent manner but scavengers of reactive oxygen species did not influence the growth inhibiting effect of interferon-gamma within J774A.1 cells. Both interferon-gamma and tumor necrosis factor-alpha enhanced the fusion of M. microti containing phagosomes with lysosomes and the ultimate degradation of bacteria. Our results showed that growth inhibition of M. microti within interferon-gamma or tumor necrosis factor-alpha stimulated J774A.1 cells was independent of reactive oxygen intermediate and reactive nitrogen intermediate production.
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| Publisher |
Wiley
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| Date |
1996-07-01
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| Type |
Article
PeerReviewed |
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| Relation |
http://onlinelibrary.wiley.com/doi/10.1111/j.1574-6968.1996.tb08332.x/pdf
http://crdd.osdd.net/open/381/ |
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| Identifier |
Gupta, R and Dogra, N and Raje, Manoj and Majumder, S (1996) Attempts to characterize the mechanisms involved in the growth inhibition of Mycobacterium microti in interferon-gamma or tumor necrosis factor-alpha activated J774A.1 cells. FEMS microbiology letters, 140 (2-3). pp. 171-8. ISSN 0378-1097
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