Effect of interleukin-1 alpha on the growth of Mycobacterium microti within J774A.1 cells.
IR@IMTECH: CSIR-Institute of Microbial Technology, Chandigarh
View Archive Info| Field | Value | |
| Title |
Effect of interleukin-1 alpha on the growth of Mycobacterium microti within J774A.1 cells.
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| Creator |
Majumdar, Sekhar
Gupta, R |
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| Subject |
QR Microbiology
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| Description |
The effect of mouse recombinant interleukin-1 alpha on the intracellular growth of Mycobacterium microti in a murine macrophage cell line J774A.1 was investigated. Interleukin-1 alpha added after infection to the M. microti-infected macrophage monolayers enhanced the growth of M. microti in a concentration-dependent manner and this growth enhancement was abrogated by neutralization of interleukin-1 alpha with anti-interleukin-1 alpha antibody. Cyclic adenosine monophosphate level in J774A.1 cells was increased by the addition of interleukin-1 alpha. Addition of dibutyryl cyclic adenosine monophosphate to infected J774A.1 cells increased the number of intracellular bacteria in a concentration-dependent manner. These results suggest that interleukin-1 alpha acts as a growth enhancer for intracellular M. microti and the growth enhancing effect of interleukin-1 alpha may be due to enhanced cellular cyclic adenosine monophosphate level.
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| Publisher |
Elsevier Science
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| Date |
1994-07-15
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://crdd.osdd.net/open/406/1/majumdar94.pdf
Majumdar, Sekhar and Gupta, R (1994) Effect of interleukin-1 alpha on the growth of Mycobacterium microti within J774A.1 cells. FEMS microbiology letters, 120 (3). pp. 329-34. ISSN 0378-1097 |
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| Relation |
http://www.sciencedirect.com/science/article/pii/0378109794904928
http://crdd.osdd.net/open/406/ |
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