Understanding the biology of 16 kDa antigen of Mycobacterium tuberculosis: scope in diagnosis, vaccine design and therapy.
IR@IMTECH: CSIR-Institute of Microbial Technology, Chandigarh
View Archive Info| Field | Value | |
| Title |
Understanding the biology of 16 kDa antigen of Mycobacterium tuberculosis: scope in diagnosis, vaccine design and therapy.
|
|
| Creator |
Siddiqui, Kaneez Fatima
Amir, Mohammed Agrewala, J N |
|
| Subject |
QR Microbiology
|
|
| Description |
Heat shock proteins (HSPs) are conserved and ubiquitous house keeping entities that act as molecular chaperones, which protect the cell from damage during stress. One such HSP, the 16 kDa antigen, from Mycobacterium tuberculosis (Mtb) has received considerable attention due to its importance in tuberculosis latency and immunodominant property. In this article, we discuss about the potential role of 16 kDa antigen of Mtb in latency, its expression, regulation, and implication in host immune response. We also highlight the scope of employing 16 kDa in early diagnosis, development of vaccine and as a potential drug target.
|
|
| Publisher |
Informa healthcare
|
|
| Date |
2011-11
|
|
| Type |
Article
PeerReviewed |
|
| Relation |
http://informahealthcare.com/doi/abs/10.3109/1040841X.2011.606425
http://crdd.osdd.net/open/450/ |
|
| Identifier |
Siddiqui, Kaneez Fatima and Amir, Mohammed and Agrewala, J N (2011) Understanding the biology of 16 kDa antigen of Mycobacterium tuberculosis: scope in diagnosis, vaccine design and therapy. Critical reviews in microbiology, 37 (4). pp. 349-57. ISSN 1549-7828
|
|