Prediction of cytochrome P450 isoform responsible for metabolizing a drug molecule.
IR@IMTECH: CSIR-Institute of Microbial Technology, Chandigarh
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| Title |
Prediction of cytochrome P450 isoform responsible for metabolizing a drug molecule.
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| Creator |
Mishra, Nitish K
Agarwal, Sandhya Raghava, G.P.S. |
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| Subject |
QR Microbiology
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| Description |
This study demonstrates that SVM based QSAR model can predict substrate specificity of major CYP isoforms with high accuracy. These models can be used to predict isoform responsible for metabolizing a drug molecule. Thus these models can used to understand whether a molecule will be metabolized or not. This is possible to develop highly accurate models for predicting substrate specificity of major isoforms using CDK descriptors. A web server MetaPred has been developed for predicting metabolizing isoform of a drug molecule http://crdd.osdd.net/raghava/metapred/.
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| Publisher |
BIomedcentral
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| Date |
2010
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://crdd.osdd.net/open/504/1/raghava10.9.pdf
Mishra, Nitish K and Agarwal, Sandhya and Raghava, G.P.S. (2010) Prediction of cytochrome P450 isoform responsible for metabolizing a drug molecule. BMC pharmacology, 10. p. 8. ISSN 1471-2210 |
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| Relation |
http://www.biomedcentral.com/content/pdf/1471-2210-10-8.pdf
http://crdd.osdd.net/open/504/ |
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