T cell help to B cells in germinal centers: putting the jigsaw together.
IR@IMTECH: CSIR-Institute of Microbial Technology, Chandigarh
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| Title |
T cell help to B cells in germinal centers: putting the jigsaw together.
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| Creator |
Gowthaman, Uthaman
Chodisetti, Sathi Babu Agrewala, J N |
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| Subject |
QR180 Immunology
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| Description |
The germinal center (GC) reaction supports the processes of affinity maturation and class switching in B cells that result in long-lasting humoral immunity. CD4(+) T follicular helper cells (Tfh) participate in the GC reaction to help B cells. However, recent studies highlight the heterogeneity of CD4(+) T cells in GCs, which confounds the understanding of Tfh cells. Based on many recent studies, we have tried to form a working model on the niche of Tfh cells in GCs. We have also addressed whether Tfh cells are a distinct lineage and how they may be generated to help B cells.
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| Publisher |
Informa healthcare
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| Date |
2010-08
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| Type |
Article
PeerReviewed |
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| Relation |
http://informahealthcare.com/doi/abs/10.3109/08830185.2010.496503
http://crdd.osdd.net/open/505/ |
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| Identifier |
Gowthaman, Uthaman and Chodisetti, Sathi Babu and Agrewala, J N (2010) T cell help to B cells in germinal centers: putting the jigsaw together. International reviews of immunology, 29 (4). pp. 403-20. ISSN 1563-5244
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