Baylis-Hillman reaction assisted parallel synthesis of 3, 5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
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| Creator |
Batra, Sanjay
Roy, Amrendra K Patra, A Bhaduri, A P Surin, W R Raghavan, S A V Sharma, P Kapoor, Kapil Dikshit, Madhu |
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| Date |
2007-11-29T10:04:05Z
2007-11-29T10:04:05Z 2004 |
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| Identifier |
Bioorg. Med. Chem., 12(9), 2059-2077
http://hdl.handle.net/123456789/34 |
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| Description |
The solution phase parallel synthesis involving reactions of Baylis-Hillman products of 3-substituted-5-isoxazolecarbaldehydes with nucleophiles and their in vivo antithrombotic evaluations are described along with the results of in vitro platelet aggregation inhibition assay of a few compounds. Results of the detailed evaluation of one of the compounds as an inhibitor of platelet aggregation are also presented.
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| Format |
300579 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No. 6468
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| Subject |
Baylis-Hillman reaction
Isoxazolecarbaldehyde isoxazole nucleophilic substitution substituted piperazine antithrombotic activity platelet aggregation |
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| Title |
Baylis-Hillman reaction assisted parallel synthesis of 3, 5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents
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| Type |
Article
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