Convenient synthesis of substituted α-methylene--valerolactones in aqueous medium using Baylis-Hillman chemistry
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Singh, Vijay
Batra, Sanjay |
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| Date |
2007-12-06T10:33:46Z
2007-12-06T10:33:46Z 2006 |
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| Identifier |
Synthesis ( 2006), 63-72
http://hdl.handle.net/123456789/36 |
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| Description |
A mild and convenient synthesis of substituted α-methylene--valerolactones was achieved by SN2 nucleophilic substitution of the acetates of the Baylis-Hillman adducts with acetyl acetone followed by one-pot saponification of the ester, reduction of the keto group and subsequent intramolecular ring closure in aqueous medium.
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| Format |
293915 bytes
application/pdf |
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| Language |
en
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| Relation |
(1) CDRI Communication No. 6732
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| Subject |
Baylis-Hillman
α-methylene--valerolactone nucleophilic substitution aqueous medium |
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| Title |
Convenient synthesis of substituted α-methylene--valerolactones in aqueous medium using Baylis-Hillman chemistry
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| Type |
Article
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