Synthesis and antibacterial evaluation of ureides of Baylis-Hillman derivatives
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Nag, Somnath
Pathak, Richa Kumar, Manish Shukla, P K Batra, Sanjay |
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| Date |
2007-12-26T10:26:00Z
2007-12-26T10:26:00Z 2006 |
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| Identifier |
Bioorganic & Medicinal Chemistry Letters, 16, 3824 (2006)
http://hdl.handle.net/123456789/51 |
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| Description |
The synthesis of several 1-(2-cyano-3-aryl-allyl)-3-aryl-urea(thiourea) constructed from the reaction between allyl amines generated from Baylis-Hillman acetates and substituted isocyanates and isothiocyanates has been described. Further their cyclization in the presence of a base led to the formation of 5-arylmethyl-4-imino-3-aryl-3,4-dihydro-1H-pyrimidin-2-ones. All compounds were tested for their antibacterial activity. Few of the compounds showed superior activity or were equipotent to the standard antibacterial agents.
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| Format |
148835 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication no. 6933
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| Subject |
Ureides
Baylis-Hillman antibacterial |
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| Title |
Synthesis and antibacterial evaluation of ureides of Baylis-Hillman derivatives
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| Type |
Article
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