CSIR Central

QSAR Studies on Thiazolidines: A Biologically Privileged Scaffold

IR@CDRI: CSIR-Central Drug Research Institute, Lucknow


Field	Value

Creator	Prabhakar, Yenamandra S Solomon, V Raja Gupta, Manish K Katti, S B

Date	2008-02-29T10:24:26Z 2008-02-29T10:24:26Z 2006

Identifier	Topics in Heterocyclic Chemistry (2006), 4, 161 http://hdl.handle.net/123456789/94

Description	A large number of drugs and biologically relevant molecules contain heterocyclic systems. Often the presence of hetero atoms or groupings imparts preferential specificities in their biological responses. Amongst the heterocyclic systems, thiazolidine is a biologically important scaffold known to be associated with several biological activities. Some of the prominent biological responses attributed to this skeleton are antiviral, antibacterial, antifungal, antihistaminic, hypoglycemic, anti-inflammatory activities. This diversity in the biological response profiles of thiazolidine has attracted the attention of many researchers to explore this skeleton to its multiple potential against several activities. Many of these synthetic and biological explorations have been subsequently analyzed in detailed quantitative structure-activity relationship (QSAR) studies to correlate the respective structural features and physicochemical properties with the activities to identify the important structural components in deciding their activity behavior. In this, drugs or any biologically active molecules may be viewed as structural frames consisting of strategically positioned functional groups that will interact effectively with the complementary groups/sites of the receptor. With this in focus, the present article reviews the QSAR studies of diverse biological activities of the thiazolidines published during the past decade.

Format	492296 bytes application/pdf

Language	en

Subject	Thiazolidines QSAR molecular modeling

Title	QSAR Studies on Thiazolidines: A Biologically Privileged Scaffold

Type	Book chapter