Synthesis of Carbamyl and Ether Analogs of Phosphatldylchollnes
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Agarwal, Kirti
Bali, Anu Gupta, C M |
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| Date |
2008-03-23T07:10:23Z
2008-03-23T07:10:23Z 1984 |
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| Identifier |
Chemistry and Physics of Lipids (1984), 36, 169-177
http://hdl.handle.net/123456789/122 |
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| Description |
A complete synthesis of I-O-hexadecyl-2-O-N-(heptadec-8-cis-enyl)carbamyl-sn-glycer0-3-
phosphocholine. a novel analog of phosphatidylcholine, has been described. Each step is simple to perform and gives the desired products in high yield. Also, some of the intermediates formed during the synthesis have been efficiently utilized to prepare 1-O-hexadecyl-2-O-oleyl-snglycero-
3-phosphocholine, I-O-hexadecyl-2-oleoyl-sll-glycero-3-phosphocholine and 3-O-hexadecyl-2-oleoyl-sn-glycero-l-phosphocholine. These phosphatidy1choline (PC) analogs are useful for studying the possible role of phospholipases in the capture and lysis of liposomes in vivo.
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| Format |
2248839 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No. 3539
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| Subject |
liposome
drug delivery plasma lipoprotein phosphatidyl analog phospholipases |
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| Title |
Synthesis of Carbamyl and Ether Analogs of Phosphatldylchollnes
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| Type |
Article
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