Antibody-mediated targeting of liposomes to red cells in vivo
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Singhal, Arun
Gupta, C M |
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| Date |
2008-03-26T07:37:48Z
2008-03-26T07:37:48Z 1986 |
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| Identifier |
FEBS Letters (1986), 201, 321-326
http://hdl.handle.net/123456789/126 |
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| Description |
Covalent attachment of anti-rat erythrocyte F(ab')2 to liposomes specifically enhanced their binding to rat
erythrocytes in vivo and reduced their uptake by the liver. Furthermore, at least 20-30% of the cell-bound
liposomes delivered their contents to the cells. Besides, the liposome binding did not affect the survival time
of the target cells at least up to 3 h in the blood circulation. These results demonstrate for the first time
that liposomes can be successfully targeted to cells other than liver cells in vivo.
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| Format |
2314844 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No. 3847
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| Subject |
Drug targeting
Liposome Cell-specific antibody F( ab') 2 fragment Erythrocyte |
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| Title |
Antibody-mediated targeting of liposomes to red cells in vivo
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| Type |
Article
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