Synthesis of Galactopyranosyl Amino Alcohols as a new class of Antitubercular and Antifungal Agents
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
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| Creator |
Tewari, Neetu
Tiwari, V K Tripathi, R P Chaturvedi, Vinita Srivastava, A Srivastava, R Shukla, P K Chaturvedi, A K Gaikwad, A Sinha, S Srivastava, B S |
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| Date |
2009-02-10T19:22:02Z
2009-02-10T19:22:02Z 2004 |
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| Identifier |
Bio. Med. Chem.Lett.12,329 (2004)
http://hdl.handle.net/123456789/312 |
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| Description |
The galactopyranosyl amino alcohols (3-16) were synthesized by regioselective oxirane ring opening of compound 2 with variety of amines and screened for antitubercular and antifungal activities. One of the compounds (16) showed potent activity against M. tuberculosis H37 Rv in vitro and also displayed activity in MDR TB. The compound (16) was found to be superior to ethambutol clinically used anti TB drug in in vitro screen.
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156349 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI communication No 6442
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| Title |
Synthesis of Galactopyranosyl Amino Alcohols as a new class of Antitubercular and Antifungal Agents
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| Type |
Article
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