Synthesis of 2-sulfanyl-6-methyl-1,4-dihydropyrimidines as a new class of antifilarial agents
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
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| Creator |
Singh, B K
Mishra, Mridul Saxena, Nisha Yadav, G P Maulik, P R Sahoo, M K Gaur, R L Murthy, P K Tripathi, R P |
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| Date |
2009-02-10T19:22:02Z
2009-02-10T19:22:02Z 2008 |
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| Identifier |
European Journal of Medicinal Chemistry 43, 2717-2723.(2008)
http://hdl.handle.net/123456789/322 |
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| Description |
A series of 2-sulfanyl-6-methyl-1,4-dihydropyrimidines (8-21) were synthesized in good yields by alkylation of 5-methyl-6-phenyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid ethyl ester (2-7) with different alkyl or aralkyl halides in presence of a combination of anhydrous K2CO3 and catalytic amount of tetrabutyl ammonium bromide. The title compounds were evaluated for their antifilarial activity against adult parasites of human lymphatic filarial parasite Brugia malayi (sub-periodic strain) in vitro and in vivo at various concentrations. One of the compounds (18) showed promising antifilarial activity.
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114182 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No. 7347
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| Subject |
Dihydropyrimidines
1,4-dihdyropyrimidines antifilarial Brugia malayi tetrabutylammonium bromide |
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| Title |
Synthesis of 2-sulfanyl-6-methyl-1,4-dihydropyrimidines as a new class of antifilarial agents
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| Type |
Article
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