Synthesis and Antimycobacterial Activities of Glycosylated Amino Alcohols and Amines
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
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| Creator |
Katiyar, D
Tiwari, V K Tewari, N Verma, S S Sinha, S Gaikwad, A Srivastava, A Chaturvedi, Vinita Srivastava, R Srivastava, B S Tripathi, R P |
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| Date |
2009-02-10T19:22:38Z
2009-02-10T19:22:38Z 2005 |
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| Identifier |
EUJMC 40, 351(2005)
http://hdl.handle.net/123456789/333 |
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| Description |
Reduction of glycosyl β-amino esters (6-14 and 25-30) with lithium aluminium hydride resulted in glycosyl amino alcohols (15-23 and 31-36) in good yields. However, reductive amination of glycosyl aldehydes (1, 2 and 3) with different amines in presence of sodium borohydride resulted in good to moderate yields of glycosyl amines (37-41). All the compounds were evaluated for antitubercular activity against M. tuberculosis H37Ra and H37Rv. Compounds 18, 21, 35 and 36 exhibited antitubercular activities with MIC ranging from 6.25 μg/mL to 3.12 μg/mL.
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256382 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication no. 6578
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| Subject |
Tuberculosis
Glycosyl amines Glycosyl amino alcohols Reductive amination MDR tuberculosis |
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| Title |
Synthesis and Antimycobacterial Activities of Glycosylated Amino Alcohols and Amines
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| Type |
Article
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