Organocatalyzed highly atom economic one pot synthesis of tetrahydropyridines as antimalarials
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Misra, Mridul
Pandey, Swaroop Kumar Pandey, Vivek Parashar Pandey, Jyoti Tripathi, Renu Tripathi, R P |
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| Date |
2009-08-31T06:34:43Z
2009-08-31T06:34:43Z 2009 |
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| Identifier |
Bioorganic & Medicinal Chemistry(2009),17,625–633
http://hdl.handle.net/123456789/484 |
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| Description |
A highly atom economic one pot synthesis of tetrahydropyridines was achieved by L-proline/TFA catalysed multicomponent reaction of β-keto-esters, aromatic aldehydes and anilines. The synthesized compounds were screened against P. falciparum in vitro and one of them showed antimalarial activity with MIC as low as 0.09 µg /mL.
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| Format |
215008 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI communication No.7466
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| Subject |
Tetrahydropyridines
Antimalarial activity L-proline Organocatalysis Schizont maturation Trifluoroacetic acid |
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| Title |
Organocatalyzed highly atom economic one pot synthesis of tetrahydropyridines as antimalarials
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| Type |
Article
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