A facile route to the synthesis of pyrimido[2,1-b]quinazoline core from the primary allyl amines afforded from Baylis-Hillman adducts
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Nag, Somnath
Mishra, Amita Batra, Sanjay |
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| Date |
2009-09-15T09:31:55Z
2009-09-15T09:31:55Z 2008 |
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| Identifier |
Tetrahedron 64 (2008) 10162–10171
http://hdl.handle.net/123456789/513 |
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| Description |
A highly simplified approach for the generation of substituted pyrimido[2,1-b]quinazoline core from the primary allyl amines afforded from the Baylis-Hillman adducts is described. Sequential reductive alkylation of the primary allyl amine with 2-nitrobenzaldehyde, reduction of the aromatic nitro group with In, CNBr-promoted intramolecular cyclization followed by NaOMe-mediated another intramolecular cyclization furnish the title compounds.
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| Format |
259422 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No 7563
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| Subject |
Baylis-Hillman
Allyl amine BrCN, pyrimido[2,1-b]quinazoline In intramolecular cyclization |
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| Title |
A facile route to the synthesis of pyrimido[2,1-b]quinazoline core from the primary allyl amines afforded from Baylis-Hillman adducts
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| Type |
Article
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