Agents Acting on the Central Nervous System: Part IX - S,6-Disubstituted6,7,8,9-Tetrahydro-sH-benzocyc1oheptenes& 8,9-Dihydro-7 H-benzocyc1oheptadiene
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
KHANNA, JM
ANAND, NITYA |
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| Date |
2010-08-23T10:31:29Z
2010-08-23T10:31:29Z 1968 |
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| Identifier |
Indian Journal of Chemistry, 6,1968,6
http://hdl.handle.net/123456789/570 |
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| Description |
A series of 6-tertiaryamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ones and their corresponding
heptenols, 8,9-dihydro-7H-benzocyloheptadiene[6,5-d]pyrazoles, and isoxazoles has
been prepared and tested for their pharmacological activity. It has been shown that in reduction
of 6-tertiaryamino-6,7,8;9-tetrahydro-5H-benzocyclohepten-5-.ones both the cis- and transisomers
are formed, the structure of which have been assigned on the basis of NMR studies.
6-(4-N-methylpiperazinyl) -6,7,8,9-tetrahydro-5H -benzocyclohepten-5-one has been found to
possess marked adrenolytic activity, while 6-(4-morpholinyl)-6,7,8,9-tetrahydro-5H-benzocyclohepten-
5-one and the corresponding heptenol shows central depressant action.
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3785431 bytes
application/pdf |
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| Language |
en
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| Subject |
Heptenols
NMR studies benzocyclohepten transisomers |
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| Title |
Agents Acting on the Central Nervous System: Part IX - S,6-Disubstituted6,7,8,9-Tetrahydro-sH-benzocyc1oheptenes& 8,9-Dihydro-7 H-benzocyc1oheptadiene
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| Type |
Article
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