Drugs Acting on CNS: Syntheses of 2-Substituted& 2,3-Disubstituted Benzo( 6,7) quinazoline-4 -ones.
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
GUPTA, C M
BHADURI, A P KHANNA, K M |
|
| Date |
2010-04-29T05:22:50Z
2010-04-29T05:22:50Z 1968 |
|
| Identifier |
Indian journal of chemistry,6,1968,621,623.
http://hdl.handle.net/123456789/553 |
|
| Description |
A series of 2-substituted and 2,3-disubstituted benzo(6,7)quinazoline-4-ones have been synthesized as possible CNS depressants. 2-Substituted products, viz. hydrazino, phenylhydrazino and amino, have been obtained by the reaction of 2-ethylthio-benzo(6,7) quinazolin-4-one with hydrazine, phenylhydrazine, and primary and secondary amines. The 2,3-disubstituted derivatives have been obtained by the reaction of 2-mercapto-3-phenyl-benzo(6,7)quinazoline-
4-one with appropriate alkyl, arylalkyl, dialkylamino-alkyl halides in the presence of alcoholic sodium hydroxide. Some of the compounds exhibit CNS-depressant activity at high dosage.
|
|
| Format |
1988371 bytes
application/pdf |
|
| Language |
en
|
|
| Subject |
CNS depressants
sodium hydroxide 2-Substituted 2,3-disubstituted |
|
| Title |
Drugs Acting on CNS: Syntheses of 2-Substituted& 2,3-Disubstituted Benzo( 6,7) quinazoline-4 -ones.
|
|
| Type |
Article
|
|