Synthesis of [l-Isoleucine-, 3-Proline-, and 5-Alanine ]-angiotensins 11
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Khosla, M C
Chaturvedi, N C Smeby, R R Bumpus, F M |
|
| Date |
2010-05-08T06:54:05Z
2010-05-08T06:54:05Z 1968 |
|
| Identifier |
Biochemistry, 7,1968,3417
http://hdl.handle.net/123456789/557 |
|
| Description |
1-Isoleucine,5-isoleucine]-angiotensin II and
[3-proline,5-isoleucine]-angiotensin II were synthesized by the solid-phase method using dicyclohexylcarbodiimide as the condensing agent. The formation of the arginyl-proline bond was extremely difficult under conditions
used. The former had about 25% pressor and
50% oxytocic activities giving further evidence the acidity of the j3-carboxyl is unnecessary. The latter possessed 40% pressor and 80% oxytocic activities of
the parent angiotensin. This relatively high biological activity was surprising because of the limitation on possible peptide conformations imposed by this cyclic
amino acid. [5-Alanine]-angiotensin II was prepared by solid phase using N-ethyl-5-phenylisoxazolium-3-sulfonate as the condensing agent. This peptide possessed
approximately 5% of pressor activity of angiotensin II indicating the importance of branched side chain of valine or isoleucine occurring naturally in this position.
|
|
| Format |
4021631 bytes
application/pdf |
|
| Language |
en
|
|
| Subject |
1-Isoleucine
dicyclohexylcarbodiimide N-ethyl-5-phenylisoxazolium-3-sulfonate angiotensin |
|
| Title |
Synthesis of [l-Isoleucine-, 3-Proline-, and 5-Alanine ]-angiotensins 11
|
|
| Type |
Article
|
|