Synthesis of oxalamide and triazine derivatives as a novel class of hybrid 4–aminoquinoline with potent antiplasmodial activity
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Sunduru, Naresh
Sharma, Moni Srivastava, Kumkum Rajakumar, S Puri, S K Saxena, J K Chauhan, P M S |
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| Date |
2010-09-04T06:33:37Z
2010-09-04T06:33:37Z 2009 |
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| Identifier |
Bioorganic & Medicinal chemistry, 17(17), 2009, 6451-6462
http://hdl.handle.net/123456789/576 |
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| Description |
Frequency of malaria and its resistance to chemotherapeutic options are emerging rapidly. To counter this problem, a series of 4–aminoquinolines having oxalamide and triazine functionalities in the side chain were synthesized and screened for their antimalarial activities. Triazine derivative 48 found to be the most active against CQ sensitive strain 3D7 of plasmodium falciparum in an in vitro assay with an IC50 of 5.23 ng/mL and oxalamide derivative 13 showed an in vivo suppression of 70.45% on day 4 against CQ resistant strain N–67 of plasmodium yoelii.
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| Format |
310494 bytes
application/pdf |
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| Language |
en
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| Subject |
malaria
Plasmodium falciparum antimalarial activities plasmodium yoelii |
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| Title |
Synthesis of oxalamide and triazine derivatives as a novel class of hybrid 4–aminoquinoline with potent antiplasmodial activity
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| Type |
Article
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