Synthesis of novel thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline as potent antimalarials
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Sunduru, Naresh
Srivastava, Kumkum Rajakumar, S Puri, S K Saxena, J K Chauhan, P M S |
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| Date |
2010-09-04T06:33:50Z
2010-09-04T06:33:50Z 2009 |
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| Identifier |
Bioorganic & Medicinal Chemistry Letters 19(9), 2009, 2570-2573
http://hdl.handle.net/123456789/577 |
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| Description |
In search of new 4-aminoquinolines which are not recognized by CQR mechanism, thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline were synthesized and screened for their antimalarial activity. Thiourea derivative 3 found to be the most active against CQ sensitive strain 3D7 of P. falciparum in an in vitro model with an IC50 of 6.07 ng/mL and also showed in vivo suppression of 99.27% on day 4 against CQ resistant strain N-67 of P. yoelii.
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| Format |
124671 bytes
application/pdf |
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| Language |
en
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| Subject |
4-aminoquinolines
antimalarial P. falciparum P. yoelii Thiazolidinedione Thiazolidinedione Thioparabanic acid |
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| Title |
Synthesis of novel thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline as potent antimalarials
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| Type |
Article
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