Substituted quinolinyl chalcones and quinolinyl pyrimidines as a new class of anti-infective agents
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Sharma, Moni
Chaturvedi, Vinita Manju, Y K Bhatnagar, Shalini Srivastava, Kumkum Puri, S K Chauhan, P M S |
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| Date |
2010-09-04T06:34:22Z
2010-09-04T06:34:22Z 2009 |
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| Identifier |
European Journal of Medicinal Chemistry , 44, 5, 2009, 2081-2091
http://hdl.handle.net/123456789/579 |
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| Description |
Frequency of tuberculosis and malaria is progressively increasing worldwide. New emerging strain of bacterium and resistance to currently available drugs make this field more conscientious and alarming. In this connection a series of substituted quinolinyl chalcones and substituted quinolinyl pyrimidines were synthesised and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37RV and antimalarial activity against NF-54 strain of Plasmodium falciparum. A comparison of structure-activity relationship reveals that different physicochemical and structural requirements exist for these two activities. Out of synthesized compounds, compound No. 18, 19 have shown antitubercular activity of MIC 3.12 µg/ml and were non toxic against VERO, MBMDM cell lines and compounds 49, 50, 51 have shown antimalarial activity of MIC 1.0 µg/ml.
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| Format |
183059 bytes
application/pdf |
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| Language |
en
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| Subject |
Tuberculosis
Malaria Chalcones Pyrimidines |
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| Title |
Substituted quinolinyl chalcones and quinolinyl pyrimidines as a new class of anti-infective agents
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| Type |
Article
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