Aryloxy cyclohexyl imidazoles: a novel class of antileishmanial agents
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Srinivas, Nagarapu
Palne, Shraddha Nishi Gupta, Suman Bhandari, Kalpana |
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| Date |
2010-09-04T06:35:15Z
2010-09-04T06:35:15Z 2009 |
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| Identifier |
Bioorganic & Medicinal Chemistry Letters,19 (2)2009,324-327
http://hdl.handle.net/123456789/581 |
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| Description |
Thirteen novel aryloxy cyclohexane based mono and bis imidazoles were synthesized and evaluated in vitro as antileishmanials against L. donovani and cytotoxicity assessed. These compounds were better than the existing drugs, sodium stibogluconate and pentamidine in respect to IC50 and SI values. Promising compounds were tested further in-vivo. Among all, the bis methylimidazole with 2-fluoro, 4-nitro aryloxy group (9) exhibited significant in vivo inhibition of 77.9 %, thus providing new structural lead for antileishmanials.
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| Format |
126925 bytes
application/pdf |
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| Language |
en
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| Subject |
Leishmania
azoles imidazoles aryloxy cyclohexane |
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| Title |
Aryloxy cyclohexyl imidazoles: a novel class of antileishmanial agents
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| Type |
Article
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