Design and Synthesis of 2-(2,6-Dibromo-phenyl)-3-heteroaryl-1,3-thiazolidin-4-ones as Anti-HIV agents
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Rawal, R K
Tripathi, R K Katti, S B Pannecouque, Christophe Clercq, E D |
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| Date |
2010-09-09T08:54:08Z
2010-09-09T08:54:08Z 2009 |
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| Identifier |
Eur. J. Med. Chem., 2009,43(12), 2800-2806
http://hdl.handle.net/123456789/596 |
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| Description |
A series of 2-(2,6-dibromophenyl)-3-heteroaryl-1,3-thiazolidin-4-ones were designed, synthesized and evaluated as selective HIV-1 RT enzyme inhibitors. The results of the HIV-1 RT kit based assay and MT-4 cell tests showed that eight compounds effectively inhibited human immunodeficiency virus type-1 (HIV-1) replication at 20-320 nM concentrations with minimal cytotoxicity in MT-4 as well as in CEM cells.
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| Format |
147679 bytes
application/pdf |
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| Language |
en
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| Subject |
4-thiazolidinones
Anti-HIV activity HIV-1RT NNRTIs |
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| Title |
Design and Synthesis of 2-(2,6-Dibromo-phenyl)-3-heteroaryl-1,3-thiazolidin-4-ones as Anti-HIV agents
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| Type |
Article
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