A convenient synthesis of chiral amino acid derived 3,4-dihydro-2H-benzo[b][1,4]thiazines and antibiotic Levofloxacin
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Parai, M K
Panda, Gautam |
|
| Date |
2010-09-09T08:54:19Z
2010-09-09T08:54:19Z 2009 |
|
| Identifier |
Tetrahedron Letters, 50 ,2009 ,4703–4705
http://hdl.handle.net/123456789/597 |
|
| Description |
A series of 3,4-dihydro-2H-benzo[b][1,4]thiazine derivatives 8a-g were synthesized via- a copper-catalyzed intramolecular N-aryl amination reaction on substituted 2-(2-bromophenylthio)-ethanamines which were synthesized by the nucleophilic substitution reaction of 2-bromobenzenethiol with Boc-protected amino alcohol derivatives. This strategy provides a short and efficient entry to (S)-3-methyl-1,4-benzoxazine 12, an advanced synthetic intermediate for the synthesis of Levofloxacin.
|
|
| Format |
45505 bytes
application/pdf |
|
| Language |
en
|
|
| Subject |
Benzothiazine
3,4-dihydro-2H-benzo[b][1,4]thiazine N-aryl amination reaction 2-bromobenzenethiol (S)-3-methyl-1,4-benzoxazine 12 Levofloxacin |
|
| Title |
A convenient synthesis of chiral amino acid derived 3,4-dihydro-2H-benzo[b][1,4]thiazines and antibiotic Levofloxacin
|
|
| Type |
Article
|
|